Structure-based design of PDK1 inhibitorsPOULSEN, Anders; BLANCHARD, Stéphanie; KAI SOH, Chang et al.Bioorganic & medicinal chemistry letters (Print). 2012, Vol 22, Num 1, pp 305-307, issn 0960-894X, 3 p.Article

Identification of potent, noncovalent fatty acid amide hydrolase (FAAH) inhibitorsGUSTIN, Darin J; ZHIHUA MA; CARLSON, Timothy J et al.Bioorganic & medicinal chemistry letters (Print). 2011, Vol 21, Num 8, pp 2492-2496, issn 0960-894X, 5 p.Article

Discovery of a new class of catalytic topoisomerase II inhibitors targeting the ATP-binding site by structure based design. Part IFURET, Pascal; SCHOEPFER, Joseph; RADIMERSKI, Thomas et al.Bioorganic & medicinal chemistry letters (Print). 2009, Vol 19, Num 15, pp 4014-4017, issn 0960-894X, 4 p.Article

Structure-Based Design and Synthesis of Novel Dual-Target Inhibitors against Cyanobacterial Fructose-1,6-Bisphosphate Aldolase and Fructose-1,6-BisphosphataseDING LI; XINYA HAN; QIDONG TU et al.Journal of agricultural and food chemistry (Print). 2013, Vol 61, Num 31, pp 7453-7461, issn 0021-8561, 9 p.Article

Vaccines based on structure-based design provide protection against infectious diseasesTHOMAS, Sunil; LUXON, Bruce A.Expert review of vaccines. 2013, Vol 12, Num 11, pp 1301-1311, issn 1476-0584, 11 p.Article

Expression and characterization of a humanized cocaine-binding antibodyREDWAN, El-Rashdy M; LARSEN, Nicholas A; BIN ZHOU et al.Biotechnology and bioengineering. 2003, Vol 82, Num 5, pp 612-618, issn 0006-3592, 7 p.Article

The discovery of potent and long-acting oral factor Xa inhibitors with tetrahydroisoquinoline and benzazepine P4 motifsWATSON, Nigel S; ADAMS, Carl; HARLING, John D et al.Bioorganic & medicinal chemistry letters (Print). 2011, Vol 21, Num 6, pp 1588-1592, issn 0960-894X, 5 p.Article

2-Aminopyrazolo[1,5-a]pyrimidines as potent and selective inhibitors of JAK2LEDEBOER, Mark W; PIERCE, Albert C; SHLYAKTER, Dina et al.Bioorganic & medicinal chemistry letters (Print). 2009, Vol 19, Num 23, pp 6529-6533, issn 0960-894X, 5 p.Article

Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with monoaryl P4 motifsKLEANTHOUS, Sawas; BORTHWICK, Alan D; HORTENSE, Eric et al.Bioorganic & medicinal chemistry letters (Print). 2010, Vol 20, Num 2, pp 618-622, issn 0960-894X, 5 p.Article

Discovery and optimization of a new class of potent and non-chiral indole-3-carboxamide-based renin inhibitorsSCHEIPER, Bodo; MATTER, Hans; STEINHAGEN, Henning et al.Bioorganic & medicinal chemistry letters (Print). 2010, Vol 20, Num 21, pp 6268-6272, issn 0960-894X, 5 p.Article

Design and synthesis of 2'-anilino-4,4'-bipyridines as selective inhibitors of c-Jun N-terminal kinase-3SWAHN, Britt-Marie; YAFENG XUE; ARZEL, Erwan et al.Bioorganic & medicinal chemistry letters (Print). 2006, Vol 16, Num 5, pp 1397-1401, issn 0960-894X, 5 p.Article

The discovery of tricyclic pyridone JAK2 inhibitors. Part 1: Hit to leadSIU, Tony; KOZINA, Ekaterina S; BOUTHILLETTE, Melaney et al.Bioorganic & medicinal chemistry letters (Print). 2010, Vol 20, Num 24, pp 7421-7425, issn 0960-894X, 5 p.Article

Structure based de novo design of novel glycogen synthase kinase 3 inhibitorsDESSALEW, Nigus; BHARATAM, Prasad V.Bioorganic & medicinal chemistry. 2007, Vol 15, Num 11, pp 3728-3736, issn 0968-0896, 9 p.Article

A two-state homology model of the hERG K⁺ channel : application to ligand bindingRAJAMANI, Ramkumar; TOUNGE, Brett A; JIAN LI et al.Bioorganic & medicinal chemistry letters (Print). 2005, Vol 15, Num 6, pp 1737-1741, issn 0960-894X, 5 p.Article

Design and synthesis of 6-anilinoindazoles as selective inhibitors of c-Jun N-terminal kinase-3SWAHN, Britt-Marie; HUERTA, Fernando; KALLIN, Elisabet et al.Bioorganic & medicinal chemistry letters (Print). 2005, Vol 15, Num 22, pp 5095-5099, issn 0960-894X, 5 p.Article

Isosteric replacements for benzothiazoles and optimisation to potent Cathepsin K inhibitors free from hERG channel inhibitionDOSSETTER, Alexander G; BOWYER, Jonathan; KRAPP, Stephan et al.Bioorganic & medicinal chemistry letters (Print). 2012, Vol 22, Num 17, pp 5563-5568, issn 0960-894X, 6 p.Article

Structure and property based design of factor Xa inhibitors: Pyrrolidin-2-ones with aminoindane and phenylpyrrolidine P4 motifsYOUNG, Robert J; ADAMS, Carl; FOSTER, Graham et al.Bioorganic & medicinal chemistry letters (Print). 2011, Vol 21, Num 6, pp 1582-1587, issn 0960-894X, 6 p.Article

The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitorsYIBIN XIANG; HIRTH, Bradford; JINYU LIU et al.Bioorganic & medicinal chemistry letters (Print). 2011, Vol 21, Num 10, pp 3050-3056, issn 0960-894X, 7 p.Article

Discovery of a factor Xa inhibitor (3R,4R)-1-(2,2-difluoro-ethyl)-pyrrolidine-3,4-dicarboxylic acid 3-[(5-chloro-pyridin-2-yl)-amide] 4-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenyl]-amide} as a clinical candidateANSELM, Lillli; BANNER, David W; PANDAY, Narendra et al.Bioorganic & medicinal chemistry letters (Print). 2010, Vol 20, Num 17, pp 5313-5319, issn 0960-894X, 7 p.Article

Structure-based design, synthesis and structure―activity relationships of dibenzosuberyl- and benzoate-substituted tropines as ligands for acetylcholine-binding proteinEDINK, Ewald; AKDEMIR, Atilla; JANSEN, Chimed et al.Bioorganic & medicinal chemistry letters (Print). 2012, Vol 22, Num 3, pp 1448-1454, issn 0960-894X, 7 p.Article

Discovery of a novel azaindole class of antibacterial agents targeting the ATPase domains of DNA gyrase and Topoisomerase IVMANCHESTER, John I; DUSSAULT, Daemian D; ROSE, Jonathan A et al.Bioorganic & medicinal chemistry letters (Print). 2012, Vol 22, Num 15, pp 5150-5156, issn 0960-894X, 7 p.Article

Structural biology of dengue virus enzymes: Towards rational design of therapeuticsNOBLE, Christian G; SHI, Pei-Yong.Antiviral research. 2012, Vol 96, Num 2, pp 115-126, issn 0166-3542, 12 p.Article

A single circularly permuted GFP sensor for inositol-1,3,4,5-tetrakisphosphate based on a split PH domainSAKAGUCHI, Reiko; ENDOH, Takashi; YAMAMOTO, Seigo et al.Bioorganic & medicinal chemistry. 2009, Vol 17, Num 20, pp 7381-7386, issn 0968-0896, 6 p.Article

Crystal structure of dengue virus methyltransferase without S-adenosyl-L-methionineNOBLE, Christian G; LI, Shi-Hua; HONGPING DONG et al.Antiviral research. 2014, Vol 111, pp 78-81, issn 0166-3542, 4 p.Article

Structure-based design of rhodanine-based acylsulfonamide derivatives as antagonists of the anti-apoptotic Bcl-2 proteinLI, Huan-Qiu; JING YANG; SHUHUA MA et al.Bioorganic & medicinal chemistry. 2012, Vol 20, Num 14, pp 4194-4200, issn 0968-0896, 7 p.Article